polewwestcoast.blogg.se

Idarucizumab is a specific reversal agent for dabigatran. Monoclonal antibody (mAb) Protein Structure Protein Chemical Formula Not Available Protein Average Weight Not Available Sequences Type Biotech Groups Approved Biologic Classification Protein Based Therapies Idarucizumab protein structure can be viewed below, with disulfide bridges at the following points: H22-H95, H149-H205, H225-L-219, L23-L93, L139-L199. Its use is associated with immediate, complete and sustained reversal of the anticoagulant effects of dabigatran. As a direct acting oral anticoagulant (DOAC), one of the risks associated with the use of dabigatran includes bleeding, espeically when given to patients at increased risk (elderly, chronic kidney disease, concomitant NSAID or warfarin use, etc).Īpproved under the tradename Praxbind (FDA), idarucizumab is indicated for the emergency treatment of dabigatran-associated bleeding in life-threatening or surgically induced situations. Idarucizumab is a humanized monoclonal antibody fragment (Fab) derived from an immunoglobulin G1 isotype molecule that binds to and inactivates the oral anticoagulant dabigatran, thereby reversing its anticoagulant effect. National Library of Medicine.Praxbind Generic Name Idarucizumab DrugBank Accession Number DB09264 Background